Name
Title | ||
|---|---|---|
Anatomically-Specific, 3D-Printed Cradles Enable In Vivo Mapping of the Bioelectrical Activation across the Gastroduodenal Junction |
Abstract | ||
|---|---|---|
Rhythmic bioelectrical 'slow waves' are a key regulatory mechanism underpinning digestion. The pyloric sphincter separates the independent slow wave and contractile behavior of the stomach and small intestine, while also regulating gastric emptying. In this study, we develop and validate anatomically-specific electrode cradles and analysis techniques in pigs, to map in vivo slow wave activation across this critical pylorus region for the first time. 3D printed electrode cradles were developed from reconstructions of magnetic resonance images, to accurately capture anatomical geometry. A low-pass Savitzky-Golay filter with an equivalent cut-off frequency of ~2 Hz was chosen as the optimal filter for analysis of both gastric and intestinal slow waves. Slow waves in the terminal antrum occurred with a frequency of
<tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\mathbf{2.81}\boldsymbol{\pm}\mathbf{0.55})$</tex>
cycles per minute (cpm), velocity of (5.04 ± 0.29) mm s-1, and amplitude of
<tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\mathbf{1.38}\boldsymbol{\pm}\mathbf{0.37})$</tex>
mV, before terminating at a zone of quiescence at the pylorus that was
<tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\mathbf{41.22}\boldsymbol{\pm}\mathbf{7.4})\mathbf{nm}$</tex>
wide. The proximal duodenal pacemaker initiated slow waves at a frequency of
<tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\mathbf{18.1}\boldsymbol{\pm}\mathbf{0.80}$</tex>
) cpm, velocity of
<tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\mathbf{11.3}\boldsymbol{\pm}\mathbf{2.4})$</tex>
mm s-1, and amplitude of
<tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(\mathbf{0.376}\boldsymbol{\pm}\mathbf{0.027})$</tex>
mV. This work enables quantitative definitions of numerous physiological features of the in vivo pylorus region, including the electrically quiescent zone and duodenal pacemaker location. Clinical Relevance- This work establishes a novel method for in vivo measurement of bioelectrical slow wave activity of the pyloric region, which is a key target for physiological investigation and clinical intervention. In the future, the methods developed here may inform diagnosis and/or treatment of functional gastrointestinal disorders. |
Year | DOI | Venue |
|---|---|---|
2022 | 10.1109/EMBC48229.2022.9871769 | 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) |
Keywords | DocType | Volume |
Animals,Duodenum,Electrodes,Muscle Contraction,Printing, Three-Dimensional,Stomach,Swine | Conference | 2022 |
ISSN | ISBN | Citations |
2375-7477 | 978-1-7281-2783-5 | 0 |
PageRank | References | Authors |
0.34 | 0 | 6 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Sam Simmonds | 1 | 0 | 0.34 |
| Leo K Cheng | 2 | 70 | 37.48 |
| Wharengaro Ruha | 3 | 0 | 0.34 |
| Andrew J Taberner | 4 | 0 | 0.34 |
| Peng Du | 5 | 10 | 11.12 |
| Timothy R Angeli-Gordon | 6 | 0 | 0.34 |