Name
Title | ||
|---|---|---|
Portable Breathalyzer for Exhaled Volatile Organic Compounds Monitoring in Lung Diseases |
Abstract | ||
|---|---|---|
Measurement of exhaled volatile organic compounds (VOC) in breath, also called exhaled volatilomes, has long been claimed to be a potential source of rapid, cost-effective, and non-invasive clinically applicable biomarkers. However, the current preclinical exploratory studies remain stagnant and questioned due to the lack of standardization collection, profiling, and robust data analysis. Thus, this study proposes a new portable device concept as instrumentation to address the measurement and profiling issue in analyzing VOC concentration from exhaled breath. In particular, the propanol concentration measurement is proposed here to monitor various lung diseases as a case study. The proposed device is based on a selective aptamer-based bio-nano-chip coupled with an agarose gel integrated seamlessly into custom-designed instrumentation as a new breathalyzer to enable a single handheld operation. The device includes an exchangeable chip compartment to allow a rapid bio-nano interface modification to detect various VOC for different applications. We ideated, designed, and simulated the working principle of the proposed portable breathalyzer to demonstrate the possibility for measuring VOC dealing with lung diseases. We anticipate the contributions here creates a framework and guide the future promotion of VOC analysis from preclinical lab investigations to clinical trials settings. |
Year | DOI | Venue |
|---|---|---|
2022 | 10.1109/MEMEA54994.2022.9856480 | 2022 IEEE INTERNATIONAL SYMPOSIUM ON MEDICAL MEASUREMENTS AND APPLICATIONS (MEMEA 2022) |
Keywords | DocType | Citations |
agarose gel, aptamer, bio-nano-chip, biosensors, breath analysis, finite element analysis (FEM), lung cancer, mobile health (mHealth), personalized medicine, point-of-care (POC), portable devices | Conference | 0 |
PageRank | References | Authors |
0.34 | 0 | 7 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Alec Chevrot | 1 | 0 | 0.34 |
| Justina Venckute | 2 | 0 | 0.34 |
| Sarah Cuesta | 3 | 0 | 0.34 |
| Ata Golparvar | 4 | 0 | 0.34 |
| Amar Kapic | 5 | 0 | 0.34 |
| Gian Luca Barbruni | 6 | 0 | 0.34 |
| Sandro Carrara | 7 | 0 | 0.34 |