Paper Info
Title
Elm Server: A New Resource For Investigating Short Functional Sites In Modular Eukaryotic Proteins
Abstract
Multidomain proteins predominate in eukaryotic proteomes. Individual functions assigned to different sequence segments combine to create a complex function for the whole protein. While on-line resources are available for revealing globular domains in sequences, there has hitherto been no comprehensive collection of small functional sites/motifs comparable to the globular domain resources, yet these are as important for the function of multidomain proteins. Short linear peptide motifs are used for cell compartment targeting, protein-protein interaction, regulation by phosphorylation, acetylation, glycosylation and a host of other post-translational modifications. ELM, the Eukaryotic Linear Motif server at http://elm.eu.org/, is a new bioinformatics resource for investigating candidate short non-globular functional motifs in eukaryotic proteins, aiming to fill the void in bioinformatics tools. Sequence comparisons with short motifs are difficult to evaluate because the usual significance assessments are inappropriate. Therefore the server is implemented with several logical filters to eliminate false positives. Current filters are for cell compartment, globular domain clash and taxonomic range. In favourable cases, the filters can reduce the number of retained matches by an order of magnitude or more.
Year
DOI
Venue
2003
10.1093/nar/gkg545
NUCLEIC ACIDS RESEARCH
Keywords
DocType
Volume
false positive,post translational modification
Journal
31
Issue
ISSN
Citations 
13
0305-1048
71
PageRank 
References 
Authors
9.81
17
28
Name
Order
Citations
PageRank
Pål Puntervoll113114.61
Rune Linding229430.01
Christine Gemünd320418.87
Sophie Chabanis-Davidson410911.70
Morten Mattingsdal57110.15
Scott Cameron615116.84
David M A Martin737826.55
Gabriele Ausiello830123.59
Barbara Brannetti911211.03
Anna Costantini10719.81
F Ferrè1119019.97
Vincenza Maselli128611.51
Allegra Via1361644.62
Gianni Cesareni14135895.28
Francesca Diella1535827.04
Giulio Superti-Furga168111.39
Lucjan S Wyrwicz1711816.76
Chenna Ramu1828636.46
Caroline McGuigan1910711.20
Rambabu Gudavalli20719.81
Ivica Letunic211650255.45
Peer Bork224451694.12
Leszek Rychlewski2355962.48
Bernhard Küster2417218.08
Manuela Helmer-Citterich2545633.41
William N Hunter268911.03
Rein Aasland2711613.15
Toby J. Gibson281210211.39