Paper Info
Title
Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal data.
Abstract
The main goal of this work was to assess the accuracy of several well-known methods which provide global (BSI and SIENA) or local (Jacobian integration) estimates of longitudinal atrophy in brain structures using Magnetic Resonance images. For that purpose, we have generated realistic simulated images which mimic the patterns of change obtained from a cohort of 19 real controls and 27 probable Alzheimer's disease patients. SIENA and BSI results correlate very well with gold standard data (BSI mean absolute error < 0.29%; SIENA < 0.44%). Jacobian integration was guided by both fluid and FFD-based registration techniques and resulting deformation fields and associated Jacobians were compared, region by region, with gold standard ones. The FFD registration technique provided more satisfactory results than the fluid one. Mean absolute error differences between volume changes given by the FFD-based technique and the gold standard were: sulcal CSF < 2.49%; lateral ventricles < 2.25%; brain < 0.36%; hippocampi < 1.42%.
Year
DOI
Venue
2007
10.1007/978-3-540-75759-7_95
MICCAI (2)
Keywords
Field
DocType
magnetic resonance image,realistic simulated longitudinal data,main goal,jacobian integration,disease patient,accuracy assessment,absolute error,local atrophy measurement technique,bsi result,probable alzheimer,longitudinal atrophy,gold standard data,brain structure,mean absolute error,gold standard
Nuclear medicine,Computer science,Mean absolute error,Atrophy,Magnetic resonance imaging
Conference
Volume
Issue
ISSN
10
Pt 2
0302-9743
ISBN
Citations 
PageRank 
3-540-75758-9
6
0.70
References 
Authors
5
7
Name
Order
Citations
PageRank
Oscar Camara123624.07
Rachael I Scahill2998.90
Julia A Schnabel31978151.49
William R Crum444832.49
Gerard R. Ridgway583146.07
Derek L G Hill62823441.79
Nick C Fox799888.47