Name
Abstract | ||
|---|---|---|
Many non-synonymous single nucleotide polymorphisms (nsSNPs) in humans are suspected to impact protein function. Here, we present a publicly available server implementation of the method SNAP (screening for non-acceptable polymorphisms) that predicts the functional effects of single amino acid substitutions. SNAP identifies over 80% of the non-neutral mutations at 77% accuracy and over 76% of the neutral mutations at 80% accuracy at its default threshold. Each prediction is associated with a reliability index that correlates with accuracy and thereby enables experimentalists to zoom into the most promising predictions. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1093/bioinformatics/btn435 | Bioinformatics |
Keywords | Field | DocType |
single amino acid substitution,functional effect,bioinformatics online,non-synonymous single nucleotide polymor-phisms,downloadable program,method snap,available server implementation,default threshold,impact protein function,supplementary information,computational biology,mutation,proteins | Computer science,Neutral mutation,Snap,Protein function,Bioinformatics,Genetics,Mutation | Journal |
Volume | Issue | ISSN |
24 | 20 | 1367-4811 |
Citations | PageRank | References |
19 | 0.88 | 11 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Yana Bromberg | 1 | 75 | 9.13 |
| Guy Yachdav | 2 | 115 | 10.71 |
| Burkhard Rost | 3 | 795 | 88.14 |