Name
Title | ||
|---|---|---|
Integration of RNA Search methods for Identifying Novel Riboswitch Patterns in Eukaryotes |
Abstract | ||
|---|---|---|
Riboswitches are RNA genetic control elements that were recently discovered in living cells. To regulate gene expression, they utilize a unique mechanism whereby small molecules bind to the aptamer or box region causing a conformational switch, without the participation of proteins. Riboswitches were initially found in the 5驴 UTR of bacteria, with successive discoveries in prokaryotes. Evidence for their existence in eukaryotes has prompted their scarce detection in that kingdom. Bioinformatics methods are needed in order to locate new riboswitch candidates. Several relevant search strategies have been developed and investigated, each having its own advantages and deficiencies. By merging several of these methods and integrating them in a hierarchical manner, it is possible to develop a combined strategy that will successfully locate potential candidates for the purpose of experimental validation. |
Year | DOI | Venue |
|---|---|---|
2005 | 10.1109/CSBW.2005.78 | CSB Workshops |
Keywords | Field | DocType |
own advantage,combined strategy,conformational switch,rna search method,experimental validation,bioinformatics method,hierarchical manner,identifying novel riboswitch patterns,gene expression,new riboswitch candidate,box region,rna genetic control element,macromolecules,genetics,microorganisms,molecular biophysics | RNA,Untranslated region,Cellular biophysics,Aptamer,Riboswitch,Computer science,Small molecule,Gene expression,Molecular biophysics,Bioinformatics | Conference |
ISBN | Citations | PageRank |
0-7695-2442-7 | 0 | 0.34 |
References | Authors | |
4 | 4 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Adaya N. Cohen | 1 | 1 | 0.69 |
| Klara Kedem | 2 | 1291 | 251.41 |
| Michal Shapira | 3 | 1 | 0.69 |
| Danny Barash | 4 | 265 | 24.21 |