Paper Info
Title
Magnetic resonance imaging of the mean venous vessel size in the human brain using transient hyperoxia.
Abstract
Vessel size imaging is an emerging magnetic resonance imaging (MRI) technique which has been demonstrated to provide clinically relevant information about microvascular morphology. While previous studies of vessel size in humans relied on MRI contrast agents or hypercapnia-induced changes in blood oxygenation, the technique described here uses transient hyperoxia to alter the venous blood oxygenation. The experimental paradigm consisted of two 3-minute intervals of breathing 100% O2 interleaved with three 2-minute intervals of breathing room air. Parametric maps of the mean venous vessel radius were calculated from changes in the blood oxygenation level dependent (BOLD) contrast which were measured using a combined spin-echo (SE) and gradient echo (GE) echo-planar imaging (EPI) sequence. The corresponding mean values in grey and white matter were r=6.5±0.3μm and r=6.2±0.3μm (n=6). While the hypercapnia technique requires a specialised gas mixture containing a low concentration of CO2 (typically 5–6%), the hyperoxia technique presented here uses the inhalation of medical oxygen (100% O2) which is routinely available in a clinical environment. Furthermore, 100% O2 is generally better tolerated than low doses of CO2 which makes this technique particularly suitable for applications in critically ill patients.
Year
DOI
Venue
2011
10.1016/j.neuroimage.2010.12.084
NeuroImage
Keywords
Field
DocType
Vessel size imaging,BOLD,Hyperoxia
Nuclear medicine,White matter,Hyperoxia,Inhalation,Cognitive psychology,Oxygenation,Hypercapnia,Breathing,Radiology,Medicine,Venous blood,Magnetic resonance imaging
Journal
Volume
Issue
ISSN
55
3
1053-8119
Citations 
PageRank 
References 
4
0.47
6
Authors
4
Name
Order
Citations
PageRank
Yuji Shen1304.07
Trevor Ahearn240.47
Matthew Clemence340.47
Christian Schwarzbauer4716.14