Paper Info
Title
Rtkdb: Database Of Receptor Tyrosine Kinase
Abstract
Receptor Tyrosine Kinases (RTK) are transmembrane receptors specifically found in metazoans. They represent an excellent model for studying evolution of cellular processes in metazoans because they encompass large families of modular proteins and belong to a major family of contingency generating molecules in eukaryotic cells: the protein kinases. Because tyrosine kinases have been under close scrutiny for many years in various species, they are associated with a wealth of information, mainly in mammals. Presently, most categories of RTK were identified in mammals, but in a near future other model species will be sequenced, and will bring us RTKs from other metazoan clades. Thus, collecting RTK sequences would provide a good starting point as a new model for comparative and evolutionary studies applying to multigene families. In this context, we are developing the Receptor Tyrosine Kinase database (RTKdb), which is the only database on tyrosine kinase receptors presently available. In this database, protein sequences from eight model metazoan species are organized under the format previously used for the HOVERGEN, HOBACGEN and NUREBASE systems. RTKdb can be accessed through the PBIL (Pole Bioinformatique Lyonnais) World Wide Web serve at http: / / pbil. univ-lyon1.fr/RTKdb/, or through the FamFetch graphical user interface available at the same address.
Year
DOI
Venue
2003
10.1093/nar/gkg036
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
protein kinase,receptor tyrosine kinase,tyrosine kinase,tyrosine kinase receptor,world wide web,protein sequence,user interface
SH2 domain,Biology,ROR1,Tyrosine,Genetics,SH3 domain,MAPK7,Receptor Protein-Tyrosine Kinases,Database,Receptor tyrosine kinase,Tyrosine kinase
Journal
Volume
Issue
ISSN
31
1
0305-1048
Citations 
PageRank 
References 
5
0.56
14
Authors
3
Name
Order
Citations
PageRank
Julien Grassot1202.18
Guy Mouchiroud250.56
Guy Perrière329240.35