Name
Title | ||
|---|---|---|
An expectation-maximization algorithm for analysis of evolution of exon-intron structure of eukaryotic genes |
Abstract | ||
|---|---|---|
We propose a detailed model of evolution of exon-intron structure of eukaryotic genes that takes into account gene-specific intron gain and loss rates, branch-specific gain and loss coefficients, invariant sites incapable of intron gain, and rate variability of both gain and loss which is gamma-distributed across sites. We develop an expectation-maximization algorithm to estimate the parameters of this model, and study its performance using simulated data. |
Year | DOI | Venue |
|---|---|---|
2005 | 10.1007/11554714_4 | Comparative Genomics |
Keywords | Field | DocType |
exon-intron structure,invariant site,account gene-specific intron gain,expectation-maximization algorithm,detailed model,loss rate,eukaryotic gene,branch-specific gain,loss coefficient,intron gain,expectation maximization algorithm,gamma distribution | Gene,Biology,Expectation–maximization algorithm,Exon,Invariant (mathematics),Intron,Bioinformatics,Genetics | Conference |
Volume | ISSN | ISBN |
3678 | 0302-9743 | 3-540-28932-1 |
Citations | PageRank | References |
4 | 0.81 | 4 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Liran Carmel | 1 | 119 | 17.99 |
| Igor B. Rogozin | 2 | 61 | 10.39 |
| Yuri I. Wolf | 3 | 540 | 76.15 |
| Eugene V. Koonin | 4 | 986 | 239.69 |