Title
TTA Lynx: a web-based service for analysis of actinomycete genes containing rare TTA codon.
Abstract
Motivation: TTA Lynx is a web-based service for finding, assessing and comparing coding sequences that contain TTA codons. This codon is most notable for being a regulatory switch that governs different aspects of the physiology of several GC-rich, Gram-positive bacteria belonging to genus Streptomyces, prolific producers of clinically important natural products. The ever-increasing pace of genome sequencing is creating a huge volume of data that could be utilized to improve our understanding of rare codons in actinomycete biology ( and other biological systems.) The service described here is designed to facilitate analysis of TTA-containing genes and to assess the importance of TTA-mediated regulation in an organism of interest. This service and its database of organisms with well-known or hypothetical TTA-based regulation provides an opportunity for the identification of such regulation on a genome-wide scale.
Year
DOI
Venue
2009
10.1093/bioinformatics/btp402
BIOINFORMATICS
Field
DocType
Volume
Data mining,Gene,Biology,Genus Streptomyces,DNA sequencing,Bioinformatics,Web service,Organism
Journal
25
Issue
ISSN
Citations 
18
1367-4803
0
PageRank 
References 
Authors
0.34
2
3
Name
Order
Citations
PageRank
Nestor Zaburannyy100.34
Bohdan Ostash200.34
Victor Fedorenko300.34