Name
Abstract | ||
|---|---|---|
We propose a computational method to comprehensively screen for pharmacogenomic pathway simulation models. A systematic model generation strategy is developed; candidate pharmacogenomic models are automatically generated from some prototype models constructed from existing literature. The parameters in the model are automatically estimated based on time-course observed gene expression data by data assimilation technique. The candidate simulation models are also ranked based on their prediction power measured by Bayesian information criterion. We generated 53 pharmacogenomic simulation models from five prototypes and applied the proposed method to microarray gene expression data of rat liver cells treated with corticosteroid. We found that some extended simulation models have higher prediction power for some genes than the original models. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1007/978-3-642-21260-4_18 | ISBRA |
Keywords | Field | DocType |
higher prediction power,data assimilation technique,original model,gene expression data,computational method,comprehensive pharmacogenomic pathway screening,candidate pharmacogenomic model,pharmacogenomic simulation model,pharmacogenomic pathway simulation model,extended simulation model,candidate simulation model,bayesian information criterion,data assimilation,simulation model | Data mining,Bayesian information criterion,Ranking,Computer science,Data assimilation,Microarray gene expression,Bioinformatics,Pharmacogenomics | Conference |
Volume | ISSN | Citations |
6674 | 0302-9743 | 4 |
PageRank | References | Authors |
0.43 | 5 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Takanori Hasegawa | 1 | 8 | 3.20 |
| Rui Yamaguchi | 2 | 180 | 26.49 |
| Masao Nagasaki | 3 | 368 | 26.22 |
| Seiya Imoto | 4 | 975 | 84.16 |
| Satoru Miyano | 5 | 2406 | 250.71 |