Name
Title | ||
|---|---|---|
Cyanobacterial response regulator PatA contains a conserved N-terminal domain (PATAN) with an alpha-helical insertion |
Abstract | ||
|---|---|---|
The cyanobacterium Anabaena (Nostoc) PCC 7120 responds to starvation for nitrogen compounds by differentiating approximately every 10th cell in the filament into nitrogen-fixing cells called heterocysts. Heterocyst formation is subject to complex regulation, which involves an unusual response regulator PatA that contains a CheY-like phosphoacceptor (receiver, REC) domain at its C-terminus. PatA-like response regulators are widespread in cyanobacteria; one of them regulates phototaxis in Synechocystis PCC 6803. Sequence analysis of PatA revealed, in addition to the REC domain, a previously undetected, conserved domain, which we named PATAN (after PatA N-terminus), and a potential helix--turn--helix (HTH) domain. PATAN domains are encoded in a variety of environmental bacteria and archaea, often in several copies per genome, and are typically associated with REC, Roadblock and other signal transduction domains, or with DNA-binding HTH domains. Many PATAN domains contain insertions of a small additional domain, termed α-clip, which is predicted to form a four-helix bundle. PATAN domains appear to participate in protein--protein interactions that regulate gliding motility and processes of cell development and differentiation in cyanobacteria and some proteobacteria, such as Myxococcus xanthus and Geobacter sulfurreducens. Contact: galperin@ncbi.nlm.nih.gov Supplementary information: http://www.ncbi.nlm.nih.gov/Complete_Genomes/SigCensus/PATAN.html |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1093/bioinformatics/btl096 | Bioinformatics |
Keywords | Field | DocType |
protein protein interaction,helix turn helix,sequence analysis,signal transduction,nitrogen | Gliding motility,Protein domain,Biology,Cell biology,Myxococcus xanthus,Anabaena,Microbiology,Bioinformatics,Response regulator,Heterocyst,Sequence analysis,Synechocystis | Journal |
Volume | Issue | ISSN |
22 | 11 | 1367-4803 |
Citations | PageRank | References |
2 | 0.43 | 6 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Kira S. Makarova | 1 | 57 | 5.84 |
| Eugene V. Koonin | 2 | 986 | 239.69 |
| Robert Haselkorn | 3 | 2 | 0.43 |
| Michael Y. Galperin | 4 | 809 | 180.44 |