Name
Title | ||
|---|---|---|
Identifying discriminative amino acids within the hemagglutinin of human influenza A H5N1 virus using a decision tree. |
Abstract | ||
|---|---|---|
Recently, the H5N1 virus has had an increasingly important impact on human life. This is because more and more people are becoming infected with this virus, and the possibility of a serious pandemic with human to human transmission is looming. This might occur if the genome of this influenza virus mutates either by antigenic drift or by antigenic shift, especially if there is a mutation of the hemagglutinin (HA) glycoprotein. The HA is the surface glycoprotein, and it binds to sialic acid of the host cell surface receptor. Thus, the combination of HA and sialic acid are central to whether influenza virus infects humans. In this study, we selected 497 HA protein sequences from the National Center for Biotechnology Information (NCBI) Influenza Resource database, and used a decision tree method to identify discriminative amino acids in the HA protein sequences that may possibly influence the binding of HA to sialic acid. Four such amino acid positions at 54, 55, 241, and 281 were identified and these may play an important role in infection by H5N1 influenza virus. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1109/TITB.2008.896871 | IEEE Transactions on Information Technology in Biomedicine |
Keywords | Field | DocType |
hemagglutinin (ha),ha protein sequence,ncbi influenza resource database,mutation,h5n1 virus,identifying discriminative amino acids,host cell surface receptor,influenza a h5n1 virus,influenza virus mutates,amino acid position,human life,microorganisms,influenza virus infects human,proteins,protein sequences,human influenza a,national center for biotechnology information,discriminative amino acid,human influenza a virus,influenza virus,molecular biophysics,sialic acid,infection,antigenic drift,human transmission,medical computing,antigenic shift,hemagglutinin glycoprotein,decision tree,decision trees,discriminative amino acids,amino acid,amino acids,indexing terms,protein engineering,glycoprotein,protein sequence | Virus,Computer science,H5N1 genetic structure,Sialic acid,Influenza A (H5N1) Virus,Hemagglutinin (influenza),Antigenic drift,Influenza A virus subtype H5N1,Antigenic shift,Virology | Journal |
Volume | Issue | ISSN |
12 | 6 | 1558-0032 |
Citations | PageRank | References |
2 | 0.56 | 1 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Li-Ching Wu | 1 | 15 | 5.03 |
| Jorng-Tzong Horng | 2 | 541 | 67.78 |
| Hsien-Da Huang | 3 | 835 | 63.83 |
| Weilong Chen | 4 | 377 | 15.92 |