Name
Abstract | ||
|---|---|---|
Recent studies have revealed that alternative splicing plays an important role in the observed protein and interaction diversity. Special microarrays allow for measuring gene expression at the exon level and thus for studying alternative transcripts and their corresponding protein domain architecture. We have developed the Cytoscape plugin DomainGraph that enables the visualization and detailed study of domain-domain interactions forming protein interaction networks. In addition, the integration of exon expression data supports the analysis of alternative splicing events and the characterization of their effects on the protein and domain interaction network. Different expression patterns between human tissues or cells can be identified by comparing the generated domain graphs.The plugin DomainGraph and the online documentation are available at http://domaingraph.bioinf.mpi-inf.mpg.de. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1093/bioinformatics/btn437 | Bioinformatics |
Keywords | Field | DocType |
domain interaction network,protein interaction network,corresponding protein domain architecture,alternative splicing event,alternative transcript,observed protein,domain graph,alternative splicing,domain interaction,different expression pattern,integrating expression data,protein domains,proteins,gene expression,interaction network | Graph,Protein domain,Visualization,Computer science,Exon,Gene expression,Alternative splicing,Interaction network,Bioinformatics,DNA microarray | Journal |
Volume | Issue | ISSN |
24 | 21 | 1367-4811 |
Citations | PageRank | References |
6 | 0.67 | 5 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Dorothea Emig | 1 | 30 | 3.58 |
| Melissa S. Cline | 2 | 271 | 43.65 |
| Thomas Lengauer | 3 | 3155 | 605.03 |
| Mario Albrecht | 4 | 8 | 1.15 |