Paper Info
Title
Epitome: Database Of Structure-Inferred Antigenic Epitopes
Abstract
Immunoglobulin molecules specifically recognize particular areas on the surface of proteins. These areas are commonly dubbed B-cell epitopes. The identification of epitopes in proteins is important both for the design of experiments and vaccines. Additionally, the interactions between epitopes and antibodies have often served as a model for protein protein interactions. One of the main obstacles in creating a database of antigen-antibody interactions is the difficulty in distinguishing between antigenic and non-antigenic interactions. Antigenic interactions involve specific recognition sites on the antibody's surface, while non-antigenic interactions are between a protein and any other site on the antibody. To solve this problem, we performed a comparative analysis of all protein-antibody complexes for which structures have been experimentally determined. Additionally, we developed a semi-automated tool that identified the antigenic interactions within the known antigen-antibody complex structures. We compiled those interactions into Epitome, a database of structure-inferred antigenic residues in proteins. Epitome consists of all known antigen/antibody complex structures, a detailed description of the residues that are involved in the interactions, and their sequence/structure environments. Interactions can be visualized using an interface to Jmol. The database is available at http://www.rostlab.org/services/epitome/.
Year
DOI
Venue
2006
10.1093/nar/gkj053
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
complex structure,immunoglobulin,protein protein interaction,design of experiment
Complementarity determining region,Epitope,Antigen,Biology,Epitome,Molecular biology,Database
Journal
Volume
Issue
ISSN
34
Database issue
0305-1048
Citations 
PageRank 
References 
11
1.94
7
Authors
4
Name
Order
Citations
PageRank
Avner Schlessinger1776.49
Yanay Ofran218214.01
Guy Yachdav311510.71
Burkhard Rost479588.14