Name
Abstract | ||
|---|---|---|
The ability of human immunodeficiency virus type 1 (HIV-1) to develop high levels of genetic diversity, and thereby acquire mutations to escape immune pressures, contributes to the difficulties in producing a vaccine. Possibly no single HIV-1 sequence can induce sufficiently broad immunity to protect against a wide variety of infectious strains, or block mutational escape pathways available to the virus after infection. The authors describe the generation of HIV-1 immunogens that minimizes the phylogenetic distance of viral strains throughout the known viral population ( the center of tree [COT]) and then extend the COT immunogen by addition of a composite sequence that includes high-frequency variable sites preserved in their native contexts. The resulting COT+ antigens compress the variation found in many independent HIV-1 isolates into lengths suitable for vaccine immunogens. It is possible to capture 62% of the variation found in the Nef protein and 82% of the variation in the Gag protein into immunogens of three gene lengths. The authors put forward immunogen designs that maximize representation of the diverse antigenic features present in a spectrum of HIV-1 strains. These immunogens should elicit immune responses against high-frequency viral strains as well as against most mutant forms of the virus. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1371/journal.pcbi.0030075 | PLOS COMPUTATIONAL BIOLOGY |
Keywords | Field | DocType |
immune response,spectrum,genetic variation,drug design,antigenic variation,genetic diversity,high frequency | Virus,Population,Viral Vaccine,Antigen,Biology,Immunogen,HIV vaccine,Genetics,Virology,Antigenic variation,Group-specific antigen | Journal |
Volume | Issue | ISSN |
3 | 4 | 1553-734X |
Citations | PageRank | References |
10 | 1.85 | 1 |
Authors | ||
9 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| David C Nickle | 1 | 23 | 3.72 |
| Morgane Rolland | 2 | 10 | 2.87 |
| Mark A. Jensen | 3 | 13 | 2.31 |
| Sergei L Kosakovsky Pond | 4 | 168 | 26.92 |
| Wenjie Deng | 5 | 20 | 3.57 |
| Mark Seligman | 6 | 10 | 1.85 |
| David Heckerman | 7 | 6951 | 1419.21 |
| James I Mullins | 8 | 24 | 5.69 |
| Nebojsa Jojic | 9 | 1397 | 165.68 |