Name
Abstract | ||
|---|---|---|
The secondary structure of an ncRNA molecule is known to play an important role in its biological functions. Aligning a known
ncRNA to a target candidate to determine the sequence and structural similarity helps in identifying de novo ncRNA molecules
that are in the same family of the known ncRNA. However, existing algorithms cannot handle complex pseudoknot structures which
are found in nature. In this paper, we propose algorithms to handle two types of complex pseudoknots: simple non-standard
pseudoknots and recursive pseudoknots. Although our methods are not designed for general pseudoknots, it already cover all
known ncRNAs in both Rfam and PseudoBase databases. A preliminary evaluation on our algorithms show that it is useful to identify
ncRNA molecules in other species which are in the same family of a known ncRNA.
|
Year | DOI | Venue |
|---|---|---|
2011 | 10.1007/978-3-642-04241-6_33 | Journal of Computational Biology |
Keywords | DocType | Volume |
biological function,general pseudoknots,complex pseudoknot structure,structural alignment,complex pseudoknots,known ncrnas,recursive pseudoknots,simple non-standard pseudoknots,pseudoknots.,ncrna molecule,non-coding rna,known ncrna,pseudobase databases,non coding rna,structure alignment,secondary structure,sequences,dynamic programming,structural similarity | Journal | 18 |
Issue | ISSN | ISBN |
1 | 0302-9743 | 3-642-04240-6 |
Citations | PageRank | References |
1 | 0.39 | 7 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Thomas K. F. Wong | 1 | 89 | 9.80 |
| Tak-Wah Lam | 2 | 1860 | 164.96 |
| Wing-Kin Sung | 3 | 1379 | 128.24 |
| Siu-Ming Yiu | 4 | 197 | 19.88 |