Abstract | ||
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Assessing variations in DNA copy number is crucial for understanding constitutional or somatic diseases, particularly cancers. The recently developed array- CGH( comparativegenomic hybridization) technology allows this to be investigated at the genomic level. We report the availability of a web tool for analysing array- CGH data. CAPweb ( CGH array Analysis Platform on the Web) is intended as a user- friendly tool enabling biologists to completely analyse CGH arrays from the raw data to the visualization and biological interpretation. The user typically performs the following bioinformatics steps of a CGH array project within CAP web: the secure upload of the results of CGH array image analysis and of the array annotation ( genomic position of the probes); first level analysis of each array, including automatic normalization of the data ( for correcting experimental biases), breakpoint detection and status assignment ( gain, loss or normal); validation or deletion of the analysis based on a summary report and quality criteria; visualization and biological analysis of the genomic profiles and results through a user- friendly interface. CAPweb is accessible at http://bioinfo.curie.fr/CAPweb. |
Year | DOI | Venue |
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2006 | 10.1093/nar/gkl215 | NUCLEIC ACIDS RESEARCH |
Keywords | Field | DocType |
image analysis,nucleic | Normalization (statistics),Annotation,Biology,Visualization,Upload,Genomics,Comparative genomic hybridization,Software,Bioinformatics,Genetics,Copy number analysis,Molecular biology | Journal |
Volume | Issue | ISSN |
34 | Web Server issue | 0305-1048 |
Citations | PageRank | References |
10 | 0.93 | 8 |
Authors | ||
7 |
Name | Order | Citations | PageRank |
---|---|---|---|
Stéphane Liva | 1 | 65 | 3.91 |
Philippe Hupé | 2 | 194 | 23.16 |
Pierre Neuvial | 3 | 117 | 9.54 |
Isabel Brito | 4 | 65 | 3.91 |
Eric Viara | 5 | 134 | 22.41 |
Philippe La Rosa | 6 | 44 | 3.80 |
Emmanuel Barillot | 7 | 950 | 165.00 |