Title
Simulation of nodules and diffuse infiltrates in chest radiographs using CT templates
Abstract
A method is proposed to simulate nodules and diffuse infiltrates in chest radiographs. This allows creation of large annotated databases for training of both radiologists and computer aided diagnosis systems. Realistic nodules and diffuse infiltrates were generated from three-dimensional templates segmented from CT data. These templates are rescaled, rotated, projected and superimposed on a radiograph. This method was compared, in an observer study, to a previously published method that simulates pulmonary nodules as perfectly spherical objects. Results show that it is hard for human observers to distinguish real and simulated nodules when using templates (AUC-values do not significantly differ from .5, p .05 for all observers). The method that produced spherical nodules performed slightly worse (AUC of one observer differs significantly from .5, p = .011). Simulation of diffuse infiltrates is challenging but also feasible (AUC=0.67 for one observer).
Year
DOI
Venue
2010
10.1007/978-3-642-15745-5_49
MICCAI (2)
Keywords
Field
DocType
observational study,three dimensional
Slightly worse,Computer science,Computer-aided diagnosis,Radiography,Radiology,Observer (quantum physics)
Conference
Volume
Issue
ISSN
13
Pt 2
0302-9743
ISBN
Citations 
PageRank 
3-642-15744-0
0
0.34
References 
Authors
4
6
Name
Order
Citations
PageRank
Geert Litjens199650.79
Laurens Hogeweg2576.66
Arnold M. R. Schilham300.34
Pim A. de Jong400.34
Max A. Viergever574385.51
B. van Ginneken640725.73