Title
Smart 4.0: Towards Genomic Data Integration
Abstract
SMART (Simple Modular Architecture Research Tool) is a web tool (http://smart.embl.de/) for the identification and annotation of protein domains, and provides a platform for the comparative study of complex domain architectures in genes and proteins. The January 2004 release of SMART contains 685 protein domains. New developments in SMART are centred on the integration of data from completed metazoan genomes. SMART now uses predicted proteins from complete genomes in its source sequence databases, and integrates these with predictions of orthology. New visualization tools have been developed to allow analysis of gene intron-exon structure within the context of protein domain structure, and to align these displays to provide schematic comparisons of orthologous genes, or multiple transcripts from the same gene. Other improvements include the ability to query SMART by Gene Ontology terms, improved structure database searching and batch retrieval of multiple entries.
Year
DOI
Venue
2004
10.1093/nar/gkh088
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
database search,data integrity,protein domains
Genome,Data integration,Protein tertiary structure,Protein domain,Annotation,Biology,Visualization,Genomics,Genetics,Simple Modular Architecture Research Tool
Journal
Volume
Issue
ISSN
32
Database issue
0305-1048
Citations 
PageRank 
References 
82
17.55
8
Authors
8
Name
Order
Citations
PageRank
Ivica Letunic11650255.45
Richard R Copley2745218.09
Steffen Schmidt323840.07
Francesca Ciccarelli418779.53
Tobias Doerks51093163.46
Jörg Schultz6347174.67
Chris P. Ponting7733283.28
Peer Bork84451694.12