Title
An ensemble based data fusion approach for early diagnosis of Alzheimer's disease
Abstract
As the number of the elderly population affected by Alzheimer's disease (AD) rises rapidly, the need to find an accurate, inexpensive and non-intrusive diagnostic procedure that can be made available to community healthcare providers is becoming an increasingly urgent public health concern. Several recent studies have looked at analyzing electroencephalogram (EEG) signals through the use of wavelets and neural networks. While showing great promise, the final outcomes of these studies have been largely inconclusive. This is mostly due to inherent difficulty of the problem, but also - perhaps - due to inefficient use of the available information, as many of these studies have used a single EEG channel for the analysis. In this contribution, we describe an ensemble of classifiers based data fusion approach to combine information from two or more sources, believed to contain complementary information, for early diagnosis of Alzheimer's disease. Our emphasis is on sequentially generating an ensemble of classifiers that explicitly seek the most discriminating information from each data source. Specifically, we use the event related potentials recorded from the Pz, Cz, and Fz electrodes of the EEG, decomposed into different frequency bands using multiresolution wavelet analysis. The proposed data fusion approach includes generating multiple classifiers trained with strategically selected subsets of the training data from each source, which are then combined through a modified weighted majority voting procedure. The implementation details and the promising outcomes of this implementation are presented.
Year
DOI
Venue
2008
10.1016/j.inffus.2006.09.003
Information Fusion
Keywords
Field
DocType
inefficient use,alzheimer's disease,available information,data source,proposed data fusion approach,training data,alzheimer’s disease,data fusion,learn++,complementary information,data fusion approach,multiresolution wavelet analysis,single eeg channel,early diagnosis,multiple classifier/ensemble systems,implementation detail,learn ++,wavelet analysis,public health,event related potential,neural network,majority voting
Population,Pattern recognition,Computer science,Event-related potential,Communication channel,Sensor fusion,Artificial intelligence,Artificial neural network,Majority rule,Electroencephalography,Machine learning,Wavelet
Journal
Volume
Issue
ISSN
9
1
Information Fusion
Citations 
PageRank 
References 
21
1.37
35
Authors
7
Name
Order
Citations
PageRank
Robi Polikar1129662.93
Apostolos Topalis21396.78
Devi Parikh32929132.01
Deborah Green4413.59
Jennifer Frymiare5211.37
John Kounios6648.18
Christopher M Clark737629.76