Name
Title | ||
|---|---|---|
Statistical prediction of protein chemical interactions based on chemical structure and mass spectrometry data. |
Abstract | ||
|---|---|---|
Prediction of interactions between proteins and chemical compounds is of great benefit in drug discovery processes. In this field, 3D structure-based methods such as docking analysis have been developed. However, the genomewide application of these methods is not really feasible as 3D structural information is limited in availability.We describe a novel method for predicting protein-chemical interaction using SVM. We utilize very general protein data, i.e. amino acid sequences, and combine these with chemical structures and mass spectrometry (MS) data. MS data can be of great use in finding new chemical compounds in the future. We assessed the validity of our method in the dataset of the binding of existing drugs and found that more than 80% accuracy could be obtained. Furthermore, we conducted comprehensive target protein predictions for MDMA, and validated the biological significance of our method by successfully finding proteins relevant to its known functions.Available on request from the authors. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1093/bioinformatics/btm266 | Bioinformatics |
Keywords | Field | DocType |
chemical interaction,novel method,statistical prediction,chemical compound,supplementary table,chemical structure,ms data,comprehensive target protein prediction,supplementary figure,mass spectrometry data,new chemical compound,structure-based method,mass spectrometry | Data mining,Drug discovery,Docking (dog),Computer science,Support vector machine,Target protein,Mass spectrometry,Bioinformatics,Chemical structure | Journal |
Volume | Issue | ISSN |
23 | 15 | 1367-4811 |
Citations | PageRank | References |
30 | 1.51 | 16 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Nobuyoshi Nagamine | 1 | 46 | 2.64 |
| Yasubumi Sakakibara | 2 | 769 | 62.91 |