Title
Markov blanket-based approach for learning multi-dimensional Bayesian network classifiers: an application to predict the European Quality of Life-5 Dimensions (EQ-5D) from the 39-item Parkinson's Disease Questionnaire (PDQ-39).
Abstract
Multi-dimensional Bayesian network classifiers (MBCs) are probabilistic graphical models recently proposed to deal with multi-dimensional classification problems, where each instance in the data set has to be assigned to more than one class variable. In this paper, we propose a Markov blanket-based approach for learning MBCs from data. Basically, it consists of determining the Markov blanket around each class variable using the HITON algorithm, then specifying the directionality over the MBC subgraphs. Our approach is applied to the prediction problem of the European Quality of Life-5 Dimensions (EQ-5D) from the 39-item Parkinson's Disease Questionnaire (PDQ-39) in order to estimate the health-related quality of life of Parkinson's patients. Fivefold cross-validation experiments were carried out on randomly generated synthetic data sets, Yeast data set, as well as on a real-world Parkinson's disease data set containing 488 patients. The experimental study, including comparison with additional Bayesian network-based approaches, back propagation for multi-label learning, multi-label k-nearest neighbor, multinomial logistic regression, ordinary least squares, and censored least absolute deviations, shows encouraging results in terms of predictive accuracy as well as the identification of dependence relationships among class and feature variables.
Year
DOI
Venue
2012
10.1016/j.jbi.2012.07.010
Journal of Biomedical Informatics
Keywords
Field
DocType
multi-dimensional bayesian network classifier,markov blanket,class variable,disease questionnaire,39-item parkinson,markov blanket-based approach,synthetic data set,disease data,life-5 dimensions,real-world parkinson,yeast data
Data mining,Data set,Variable-order Bayesian network,Computer science,Markov chain,Least absolute deviations,Bayesian network,Artificial intelligence,Markov blanket,Graphical model,Class variable,Machine learning
Journal
Volume
Issue
ISSN
45
6
1532-0480
Citations 
PageRank 
References 
6
0.44
9
Authors
4
Name
Order
Citations
PageRank
Hanen Borchani11317.49
Concha Bielza290972.11
Pablo Martı Nez-Martı N360.44
Pedro Larrañaga43882208.54