Name
Abstract | ||
|---|---|---|
Close to 60% of protein sequences tracked in comprehensive databases can be mapped to a known three-dimensional (3D) structure by standard sequence similarity searches. Potentially, a great deal can be learned about proteins or protein families of interest from considering 3D structure, and to this day 3D structure data may remain an underutilized resource. Here we present enhancements in the Molecular Modeling Database (MMDB) and its data presentation, specifically pertaining to biologically relevant complexes and molecular interactions. MMDB is tightly integrated with NCBI's Entrez search and retrieval system, and mirrors the contents of the Protein Data Bank. It links protein 3D structure data with sequence data, sequence classification resources and PubChem, a repository of small-molecule chemical structures and their biological activities, facilitating access to 3D structure data not only for structural biologists, but also for molecular biologists and chemists. MMDB provides a complete set of detailed and pre-computed structural alignments obtained with the VAST algorithm, and provides visualization tools for 3D structure and structure/sequence alignment via the molecular graphics viewer Cn3D. MMDB can be accessed at http://www.ncbi.nlm.nih.gov/structure. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1093/nar/gkr1162 | NUCLEIC ACIDS RESEARCH |
Keywords | Field | DocType |
protein conformation,nucleic | Sequence alignment,Molecular Modeling Database,Protein structure database,Biology,Molecular graphics,Entrez,PubChem,Bioinformatics,Computational biology,Genetics,Protein Data Bank,Protein structure | Journal |
Volume | Issue | ISSN |
40 | D1 | 0305-1048 |
Citations | PageRank | References |
12 | 0.90 | 4 |
Authors | ||
15 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Thomas Madej | 1 | 212 | 195.38 |
| Kenneth J Addess | 2 | 167 | 65.65 |
| Jessica H Fong | 3 | 176 | 17.28 |
| Lewis Y. Geer | 4 | 1060 | 340.18 |
| Renata C. Geer | 5 | 250 | 17.98 |
| Christopher J Lanczycki | 6 | 426 | 172.22 |
| Chunlei Liu | 7 | 351 | 171.80 |
| Shennan Lu | 8 | 293 | 21.83 |
| Aron Marchler-bauer | 9 | 1175 | 339.48 |
| Anna R. Panchenko | 10 | 907 | 252.52 |
| Jie Chen | 11 | 2487 | 353.65 |
| Paul A. Thiessen | 12 | 521 | 232.54 |
| Yanli Wang | 13 | 1089 | 270.38 |
| Dachuan Zhang | 14 | 328 | 42.36 |
| Stephen H. Bryant | 15 | 2295 | 488.12 |