Paper Info
Title
Sensitivity of synaptic plasticity to the ca2+ permeability of nmda channels: A model of long-term potentiation in hippocampal neurons
Abstract
We have examined a model by Holmes and Levy (1990) of the induction of associative long-term potentiation (LTP) by a rise in the free Ca2+ concentration ([Ca2+]) after synaptic activation of dendritic spines. The previously reported amplification of the change in [Ca2+] caused by coactivation of several synapses was found to be quite sensitive to changes in the permeability of the N-methyl-D-aspartate (NMDA) receptor channels to Ca2+. Varying this parameter indicated that maximum amplification is obtained at values that are close to Ca2+ permeabilities reported in the literature. However, amplification failed if permeability is reduced by more than 50%. We also found that the maximum free [Ca2+] reached in an individual spine during synaptic coactivation of several spines depended on the location of that spine on the dendritic tree. Distal spines attained a higher [Ca2+] than proximal ones, with differences of up to 80%. The implications of this result for the uniformity of induction of associative LTP in spines in different regions of the dendrite are discussed.
Year
DOI
Venue
1993
10.1162/neco.1993.5.5.681
Neural Computation
Keywords
Field
DocType
nmda channel,synaptic activation,individual spine,dendritic spine,dendritic tree,synaptic coactivation,associative ltp,free ca2,maximum amplification,distal spine,associative long-term potentiation,synaptic plasticity,hippocampal neuron,long term potentiation,nmda receptor
Long-term potentiation,Synapse,Neuroscience,Dendritic spine,NMDA receptor,Coactivation,Synaptic plasticity,Hippocampal formation,Mathematics,Dendrite
Journal
Volume
Issue
ISSN
5
5
0899-7667
Citations 
PageRank 
References 
5
1.60
3
Authors
2
Name
Order
Citations
PageRank
Erik De Schutter130750.62
James M. Bower2477113.09