Name
Abstract | ||
|---|---|---|
Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure arise as emergent properties of the integrated system. The results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function. |
Year | DOI | Venue |
|---|---|---|
2014 | 10.1371/journal.pcbi.1003634 | PLOS COMPUTATIONAL BIOLOGY |
Keywords | Field | DocType |
biomedical research,bioinformatics | Sympathetic nervous system,Heart failure,Baroreflex,Biology,Pulse pressure,Stroke,Kidney disease,Blood pressure,Bioinformatics,Vascular resistance | Journal |
Volume | Issue | Citations |
10 | 5 | 2 |
PageRank | References | Authors |
0.58 | 0 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Klas H. Pettersen | 1 | 94 | 9.03 |
| Scott M. Bugenhagen | 2 | 2 | 0.58 |
| Javaid Nauman | 3 | 2 | 0.58 |
| D A Beard | 4 | 96 | 14.18 |
| Stig W. Omholt | 5 | 2 | 0.58 |