Name
Abstract | ||
|---|---|---|
•We propose hybrid kinetic/FBA models as an enhancement of traditional FBA.•Hybrids models are built with stoichiometric information and selected kinetics.•Resulting models are optimized via a tailored outer approximation.•Few kinetics suffice to dramatically improve accuracy of standalone FBA models.•Key velocities to be included are those reducing the degrees of freedom of network. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1016/j.compchemeng.2014.06.011 | Computers & Chemical Engineering |
Keywords | Field | DocType |
Metabolic engineering,FBA,GMA,Global optimization,Kinetic models | Flux distribution,Mathematical optimization,Cellular organisms,Computer science,Local optimum,Linear programming,Kinetic equations,Global optimality,Kinetic energy,Flux balance analysis | Journal |
Volume | ISSN | Citations |
72 | 0098-1354 | 1 |
PageRank | References | Authors |
0.35 | 5 | 6 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Carlos Pozo | 1 | 33 | 3.63 |
| Antoni Miró | 2 | 1 | 0.35 |
| Gonzalo Guillén-Gosálbez | 3 | 189 | 20.22 |
| Albert Sorribas | 4 | 66 | 7.81 |
| Rui Alves | 5 | 196 | 32.99 |
| Laureano Jiménez | 6 | 72 | 9.11 |