Name
Abstract | ||
|---|---|---|
In this paper we aim to quantify the effect of the inner limiting membrane (ILM) of the retina on the thresholds for epiretinal electrical stimulation of retinal ganglion cells by a microelectronic retinal prosthesis. A pair of bipolar stimulating electrodes was placed either above (on the epiretinal surface) or below the ILM while we made whole-cell patch-clamp recordings from retinal ganglion cells in an isolated rat retinal whole-mount preparation. Across our cell population we found no significant difference in the median threshold stimulus amplitudes when the stimulating electrodes were placed below as opposed to above the ILM (p = 0.08). However, threshold stimulus amplitudes did tend to be lower when the stimulating electrodes were placed below the ILM (30 µA vs 56 µA). |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1109/EMBC.2012.6346592 | EMBC |
Keywords | Field | DocType |
eye,cellular biophysics,bioelectric potentials,isolated rat retinal whole-mount preparation,epiretinal electrical stimulation,biomedical optical imaging,prosthetics,retinal ganglion cells,microelectronic retinal prosthesis,cell population,bipolar stimulating electrodes,biomembranes,inner limiting membrane,biomedical electronics,whole-cell patch-clamp recordings | Biomedical engineering,Population,Retinal ganglion,Retina,Computer science,Retinal,Stimulus (physiology),Retinal Prosthesis,Inner limiting membrane,Stimulation | Conference |
Volume | ISSN | ISBN |
2012 | 1557-170X | 978-1-4577-1787-1 |
Citations | PageRank | References |
1 | 0.48 | 1 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Shaun L. Cloherty | 1 | 21 | 9.18 |
| Raymond C S Wong | 2 | 1 | 0.48 |
| Alex E Hadjinicolaou | 3 | 1 | 2.51 |
| Hamish Meffin | 4 | 11 | 4.92 |
| Michael R. Ibbotson | 5 | 11 | 4.22 |
| Brendan J O'Brien | 6 | 1 | 0.48 |