Paper Info
Title
In Vivo tumor interstitial fluid pressure measurement using static micro force sensor and mechanical tumor model
Abstract
The interstitial fluid pressure (IFP) plays a major role in tumor formation. Increased IFP may hinder the tran-scapillary transport of therapeutic agents as well as the large molecules, and may also lead to a poor prognosis for some cancer patients. IFP may therefore be an important biomarker. Serial noninvasive IFP measurement in vivo may facilitate drug development, if quantitative IFP data could be used for comparison. This paper proposes a novel technique employing a drift-compensated numerical Polyvinylidene Fluoride (PVDF) micro-force sensor and a load-deformation mechanical model of tumor to estimate the IFP. Experiments are carried out to verify the feasibility of the method and convincing data show its potential for in vivo tumor pressure measurement.
Year
DOI
Venue
2014
10.1109/AIM.2014.6878142
AIM
Keywords
Field
DocType
biomechanics,blood pressure measurement,cancer,deformation,drugs,force sensors,microsensors,patient diagnosis,polymers,tumours,cancer patients,drift-compensated numerical polyvinylidene fluoride microforce sensor,in vivo tumor interstitial fluid pressure measurement,in vivo tumor pressure measurement,load-deformation mechanical model,mechanical tumor model,prognosis,serial noninvasive ifp measurement in vivo,static microforce sensor,therapeutic agents,tumor formation,force,calibration,pressure measurement
Biomedical engineering,Force sensor,Tumor Interstitial Fluid Pressure Measurement,Computer science,Pressure measurement,Interstitial fluid,In vivo
Conference
ISSN
Citations 
PageRank 
2159-6255
0
0.34
References 
Authors
0
9
Name
Order
Citations
PageRank
Zhiyong Sun122.06
Ruiguo Yang2165.97
pavlo l kovalenko300.34
Bo Song4103.76
Liangliang Chen5187.52
mary f walsh600.34
Lina Hao7511.02
marc d basson800.34
Ning Xi91422228.89