Title
Solving the PIHNA model while accounting for radiotherapy
Abstract
Glioblastoma is the most aggressive type of glioma. During the last decades, several models have been proposed for simulating the growth procedure of glioma. One of the latest proposed models builds upon the proliferation - diffusion model by incorporating the angiogenic net rates and different concentration of cell populations (normoxic, hypoxic and necrotic). This proliferation- invasion- hypoxia- necrosis-angiogenesis model (PIHNA) does not take into account radiotherapy. This work presents the mathematical foundation for solving PIHNA model in two dimensions with incorporated radiotherapy effect using the Linear Quadratic Model, which uses radiobiology parameters.
Year
Venue
Keywords
2012
IARWISOI
biodiffusion,brain,cancer,cellular biophysics,mathematical analysis,radiation therapy,pihna model,angiogenic net rates,cell population concentration,fatal brain cancer,glioblastoma,glioma,linear quadratic model,mathematical foundation,proliferation-diffusion model,proliferation-invasion-hypoxia-necrosis-angiogenesis model,radiobiology parameters,radiotherapy
Field
DocType
ISBN
Applied mathematics,Neuroscience,Cellular biophysics,Glioblastoma,Glioma,Linear quadratic,Radiation therapy,Radiobiology,Medicine
Conference
978-1-4673-5024-2
Citations 
PageRank 
References 
0
0.34
3
Authors
6
Name
Order
Citations
PageRank
alexandros roniotis100.34
Vangelis Sakkalis211023.68
eleftheria tzamali300.34
georgios tzedakis400.34
Michalis Zervakis519921.30
Kostas Marias6184.73