Name
Title | ||
|---|---|---|
Documentation in pharmacovigilance: using an ontology to extend and normalize Pubmed queries. |
Abstract | ||
|---|---|---|
Objectives: To assess and understand adverse drug reactions (ADRs), a systematic review of reference databases like Pubmed is a necessary and mandatory step in Pharmacovigilance. In order to assist pharmacovigilance team with a computerized tool, we performed a comparative study of 4 different approaches to query Pubmed through ADR-drug terms. The aim of this study is to assess how an ontology of adverse effects, used to normalize and extend queries, could improve this search. Material and Method: The ontological resource OntoEIM contains 58,000 classes and integrates MedDRA terminology. The entry point is a ADR-Drug term and the four methods are (i) a direct search on Pubmed (ii) a search with a normalized query enhanced with domain-specific Mesh Heading criteria, (iii) a search with the same elaborated query extended to the MeSH sub-hierarchy of the adverse effect entry and (iv) a search with a set of MedDRA terms grouped by subsomption in the OntoEIM ontology. For each of the 16 queries performed and analysed, relevant publications are selected "manually" by two pharmacovigilant experts. Results: The recall is respectively of 63%, 50%, 67% and 74%, the precision of 13%, 26%, 29% and 4%. The best recall is provided by the ontology-based method, for 4 cases out of 16 this method returns relevant publications when the others return no results. Conclusion: Results show that an ontology-based search tool improves the recall performance, but other tools and methods are needed to raise the precision. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.3233/978-1-60750-588-4-518 | Studies in Health Technology and Informatics |
Keywords | Field | DocType |
Adverse drug reaction reporting,Adverse drug reaction,Information retrieval,Databases bibliographic,PubMed,Ontology | Ontology,Data mining,MedDRA,Normalization (statistics),Information retrieval,Terminology,Computer science,Entry point,Pharmacovigilance,Documentation,Recall | Conference |
Volume | Issue | ISSN |
160 | Pt 1 | 0926-9630 |
Citations | PageRank | References |
4 | 0.52 | 0 |
Authors | ||
8 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Denis Delamarre | 1 | 5 | 1.63 |
| Agnès Lillo-Le Louët | 2 | 5 | 1.22 |
| Laetitia Guillot | 3 | 6 | 0.93 |
| Anne Jamet | 4 | 4 | 0.52 |
| Eric Sadou | 5 | 4 | 0.52 |
| Theo Ouazine | 6 | 4 | 0.52 |
| Burgun A | 7 | 141 | 14.77 |
| Marie-Christine Jaulent | 8 | 375 | 68.72 |