Name
Title | ||
|---|---|---|
Functional Connectivity Between Layer 2/3 And Layer 5 Neurons In Prefrontal Cortex Of Nonhuman Primates During A Delayed Match-To-Sample Task |
Abstract | ||
|---|---|---|
The prefrontal cortex (PFC) has been postulated to play critical roles in cognitive control and the formation of long-term memories. To gain insights into the neurobiological mechanism of such high-order cognitive functions, it is important to understand the input-output transformational properties of the PFC micro-circuitry. In this study, we identify the functional connectivity between the Layer 2/3 (input) neurons and the Layer 5 (output) neurons using a previously developed generalized Volterra model (GVM). Input-output spike trains are recorded from the PFCs of nonhuman primates performing a memory-dependent delayed match-to-sample task with a customized conformal ceramic multi-electrode array. The GVM describes how the input spike trains are transformed into the output spike trains by the PFC micro-circuitry and represents the transformation in the form of Volterra kernels. Results show that Layer 2/3 neurons have strong and transient facilitatory effects on the firings of Layer 5 neurons. The magnitude and temporal range of the input-output nonlinear dynamics are strikingly different from those of the hippocampal CA3-CA1. This form of functional connectivity may have important implications to understanding the computational principle of the PFC. |
Year | DOI | Venue |
|---|---|---|
2012 | 10.1109/EMBC.2012.6346485 | 2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) |
Keywords | Field | DocType |
neurophysiology,zoology,cognition | Neuroscience,Neurophysiology,Computer science,Prefrontal cortex,Volterra equations,Match-to-sample task,Cognition,Hippocampal formation | Conference |
Volume | ISSN | Citations |
2012 | 1557-170X | 0 |
PageRank | References | Authors |
0.34 | 3 | 7 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Dong Song | 1 | 202 | 34.25 |
| Ioan Opris | 2 | 0 | 0.68 |
| Rosa H M Chan | 3 | 182 | 22.79 |
| Vasilis Z Marmarelis | 4 | 21 | 4.16 |
| Robert E Hampson | 5 | 0 | 0.34 |
| Sam A. Deadwyler | 6 | 8 | 1.67 |
| theodore w berger | 7 | 47 | 11.18 |