Name
Abstract | ||
|---|---|---|
The myelin g-ratio, defined as the ratio between the inner and the outer diameter of the myelin sheath, is a fundamental property of white matter that can be computed from a simple formula relating the myelin volume fraction to the fiber volume fraction or the axon volume fraction. In this paper, a unique combination of magnetization transfer, diffusion imaging and histology is presented, providing a novel method for in vivo magnetic resonance imaging of the axon volume fraction and the myelin g-ratio. Our method was demonstrated in the corpus callosum of one cynomolgus macaque, and applied to obtain full-brain g-ratio maps in one healthy human subject and one multiple sclerosis patient. In the macaque, the g-ratio was relatively constant across the corpus callosum, as measured by both MRI and electron microscopy. In the human subjects, the g-ratio in multiple sclerosis lesions was higher than in normal appearing white matter, which was in turn higher than in healthy white matter. Measuring the g-ratio brings us one step closer to fully characterizing white matter non-invasively, making it possible to perform in vivo histology of the human brain during development, aging, disease and treatment. |
Year | DOI | Venue |
|---|---|---|
2015 | 10.1016/j.neuroimage.2015.05.023 | NeuroImage |
Keywords | Field | DocType |
Myelin g-ratio,Magnetization transfer,Quantitative MRI,Diffusion,Histology,White matter microstructure | White matter,Multiple sclerosis,Cognitive psychology,Psychology,Axon,Magnetization transfer,Human brain,Corpus callosum,Nuclear magnetic resonance,Pathology,Magnetic resonance imaging,Myelin | Journal |
Volume | ISSN | Citations |
118 | 1053-8119 | 37 |
PageRank | References | Authors |
1.22 | 12 | 19 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Nikola Stikov | 1 | 104 | 7.79 |
| Jennifer S W Campbell | 2 | 255 | 18.91 |
| Thomas Stroh | 3 | 37 | 1.22 |
| Mariette Lavelée | 4 | 37 | 1.22 |
| Stephen Frey | 5 | 66 | 3.44 |
| Jennifer Novek | 6 | 37 | 1.22 |
| Stephen Nuara | 7 | 37 | 1.22 |
| Ming-Kai Ho | 8 | 37 | 1.22 |
| Barry J. Bedell | 9 | 43 | 2.13 |
| Robert F Dougherty | 10 | 110 | 7.20 |
| Ilana R. Leppert | 11 | 48 | 1.74 |
| Mathieu Boudreau | 12 | 48 | 2.08 |
| Sridar Narayanan | 13 | 166 | 11.38 |
| Tanguy Duval | 14 | 83 | 5.27 |
| Julien Cohen-Adad | 15 | 472 | 29.21 |
| Paul-Alexandre Picard | 16 | 37 | 1.22 |
| Alicja Gasecka | 17 | 44 | 1.73 |
| Daniel Côté | 18 | 44 | 1.73 |
| G Bruce Pike | 19 | 699 | 132.31 |