Paper Info
Title
Dynamics of cortical neurovascular coupling analyzed by simultaneous DC-magnetoencephalography and time-resolved near-infrared spectroscopy
Abstract
Functional magnetic resonance imaging (fMRI) visualizes activated brain areas with a high spatial resolution. The activation signal is determined by the local change of cerebral blood oxygenation, blood volume and blood flow which serve as surrogate marker for the neuronal signal itself. Here, the complex coupling between these parameters and the electrophysiologic activity is characterized non-invasively in humans during a simple motor task using simultaneously DC-magnetoencephalography (DC-MEG), for the detection of neuronal signals, and time-resolved near-infrared spectroscopy (trNIRS), for cortical metabolic/vascular responses: over the left primary motor cortex hand area of healthy subjects DC-fields and trNIRS parameters followed closely the 30 s motor task cycles, i.e., finger movements of the right hand alternating with rest. In subjects showing a sufficient signal-to-noise ratio the analysis of variance of photon time of flight proved that the task-related trNIRS changes originated from the cortex. While onset and relaxation started simultaneously, trNIRS signals reached 50% of the maximum level 1–4 s later than the DC-MEG-signals. The non-invasive ‘dual’ setup helps to characterize simultaneously the two complementary aspects of the ‘hemodynamic inverse problem’, i.e., the coupling of neuronal and vascular/metabolic signals, in healthy subjects and provides a new analysis perspective for pathophysiological coupling concepts in diverse diseases, e.g., in stroke, hypertension and Alzheimer’s disease.
Year
DOI
Venue
2008
10.1016/j.neuroimage.2007.09.037
NeuroImage
Keywords
Field
DocType
Neurovascular coupling,Functional brain mapping,DC-magnetoencephalography (DC-MEG),DC-electroencephalography (DC-EEG),Near-infrared spectroscopy (NIRS),Spreading depression
Cortex (botany),Hemodynamics,Cortical spreading depression,Neuroscience,Blood flow,Functional magnetic resonance imaging,Stroke,Psychology,Blood volume,Magnetoencephalography
Journal
Volume
Issue
ISSN
39
3
1053-8119
Citations 
PageRank 
References 
10
0.96
2
Authors
9
Name
Order
Citations
PageRank
Bruno-Marcel Mackert1131.57
Stefanie Leistner2131.57
T. h. Sander3809.46
Adam Liebert4153.92
Heidrun Wabnitz5634.15
Martin Burghoff6162.21
Lutz Trahms7496.14
R Macdonald8275.28
Gabriel Curio91220201.67