Name
Title | ||
|---|---|---|
Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology. |
Abstract | ||
|---|---|---|
BackgroundThe recent outbreak of Ebola has been cited as the largest in history. Despite this global health crisis, few drugs are available to efficiently treat Ebola infections. Drug repurposing provides a potentially efficient solution to accelerating the development of therapeutic approaches in response to Ebola outbreak. To identify such candidates, we use an integrated structural systems pharmacology pipeline which combines proteome-scale ligand binding site comparison, protein-ligand docking, and Molecular Dynamics (MD) simulation. |
Year | DOI | Venue |
|---|---|---|
2016 | 10.1186/s12859-016-0941-9 | BMC Bioinformatics |
Keywords | Field | DocType |
Drug repositioning, Infectious disease, Indinavir, Sinefungin, Binding site similarity, RNA-directed RNA polymerase, VP24 | Ebolavirus,Drug repositioning,Biology,Docking (dog),Ebola virus,Pharmacology,Bioinformatics,Virology,Virulence,RNA-Directed RNA Polymerase,Infectious disease (medical specialty),Global health | Journal |
Volume | Issue | ISSN |
17 | 1 | 1471-2105 |
Citations | PageRank | References |
1 | 0.38 | 24 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Zheng Zhao | 1 | 1 | 0.38 |
| Che L Martin | 2 | 1 | 0.72 |
| Raymond Fan | 3 | 1 | 0.38 |
| Philip E. Bourne | 4 | 1995 | 388.17 |
| Lei Xie | 5 | 441 | 39.48 |