Paper Info
Title
The Reactome pathway Knowledgebase.
Abstract
The Reactome Knowledgebase (www.reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism and other cellular processes as an ordered network of molecular transformations-an extended version of a classic metabolic map, in a single consistent data model. Reactome functions both as an archive of biological processes and as a tool for discovering unexpected functional relationships in data such as gene expression pattern surveys or somatic mutation catalogues from tumour cells. Over the last two years we redeveloped major components of the Reactome web interface to improve usability, responsiveness and data visualization. A new pathway diagram viewer provides a faster, clearer interface and smooth zooming from the entire reaction network to the details of individual reactions. Tool performance for analysis of user datasets has been substantially improved, now generating detailed results for genome-wide expression datasets within seconds. The analysis module can now be accessed through a RESTFul interface, facilitating its inclusion in third party applications. A new overview module allows the visualization of analysis results on a genome-wide Reactome pathway hierarchy using a single screen page. The search interface now provides auto-completion as well as a faceted search to narrow result lists efficiently.
Year
DOI
Venue
2018
10.1093/nar/gkv1351
NUCLEIC ACIDS RESEARCH
DocType
Volume
Issue
Journal
44
D1
ISSN
Citations 
PageRank 
0305-1048
7
0.58
References 
Authors
1
22
Name
Order
Citations
PageRank
Antonio Fabregat1607.42
Konstantinos Sidiropoulos2274.96
Phani Garapati345226.00
Marc Gillespie480659.41
Kerstin Hausmann570.58
Robin Haw631516.90
Bijay Jassal778159.93
Steven Jupe829414.30
Florian Korninger9110.96
Sheldon J. McKay10714.48
Lisa Matthews1180960.14
Bruce May1245526.05
Marija Milacic131366.43
Karen Rothfels141376.80
Veronica Shamovsky1531614.44
Marissa Webber1680.95
Joel Weiser171356.46
Mark Williams181295.70
Guanming Wu1952434.98
Lincoln D. Stein201555247.25
Henning Hermjakob212433304.84
Peter D'Eustachio2289066.20