Title | ||
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A Smart Mobile Lab-on-Chip-Based Medical Diagnostics System Architecture Designed for Evolvability |
Abstract | ||
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Unprecedented knowledge levels in life sciences along with technological advances in micro-and nanotechnologies and microfluidics have recently conditioned the advent of Lab-on-Chip (LoC) devices for In-Vitro Medical Testing (IVMT). Combined with smart-mobile technologies, LoCs are pervasively giving rise to opportunities to better diagnose disease, predict and monitor personalised treatment efficacy, or provide healthcare decision-making support at the Point-of-Care (PoC). Although made increasingly available to the consumer market, the adoption of LoC-based PoC In-Vitro Medical Testing (IVMT) systems is still in its infancy. This attrition partly pertains to the intricacy of designing and developing complex systems, destined to be used sporadically, in a fast-pace evolving technological paradigm. System evolvability is therefore key in the design process and constitutes the main motivation for this work. We introduce a smart-mobile and LoC-based system architecture designed for evolvability. By propagating LoC programmability, instrumentation, and control tools to the high-level abstraction smart-mobile software layer, our architecture facilitates the realisation of new use-cases and the accommodation for incremental LoC-technology developments. We demonstrate these features with an implementation allowing the interfacing of LoCs embedding current-or impedance-based biosensors such as Silicon Nanowire Field Effect Transistors (SiNW-FETs) or electrochemical transducers. Structural modifications of these LoCs or changes in their specific operation may be addressed by the sole reengineering of the mobile-software layer, minimising system upgrade development and validation costs and efforts. |
Year | DOI | Venue |
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2015 | 10.1109/DSD.2015.11 | Euromicro Symposium on Digital Systems Design |
Keywords | Field | DocType |
Lab-on-Chip, Smartphone, Point-of-Care, In-Vitro Medical Diagnostics, System Evolvability, System Architecting | Systems engineering,Computer science,Evolvability,Technological paradigm,Interfacing,Real-time computing,Upgrade,Engineering design process,Systems architecture,Business process reengineering,Lab-on-a-chip,Embedded system | Conference |
Citations | PageRank | References |
0 | 0.34 | 5 |
Authors | ||
5 |
Name | Order | Citations | PageRank |
---|---|---|---|
Francois Patou | 1 | 0 | 0.34 |
Maria Dimaki | 2 | 23 | 8.42 |
Winnie E. Svendsen | 3 | 5 | 3.57 |
Klaus Kjaegaard | 4 | 0 | 0.34 |
Jan Madsen | 5 | 576 | 56.90 |