Title
Reactome pathway analysis: a high-performance in-memory approach.
Abstract
Through the use of highly optimised, in-memory data structures and algorithms, Reactome has achieved a stable, high performance pathway analysis service, enabling the analysis of genome-wide datasets within seconds, allowing interactive exploration and analysis of high throughput data. The proposed pathway analysis approach is available in the Reactome production web site either via the AnalysisService for programmatic access or the user submission interface integrated into the PathwayBrowser. Reactome is an open data and open source project and all of its source code, including the one described here, is available in the AnalysisTools repository in the Reactome GitHub ( https://github.com/reactome/ ).
Year
DOI
Venue
2017
10.1186/s12859-017-1559-2
BMC Bioinformatics
Keywords
Field
DocType
Data structures,Over-representation analysis,Pathway analysis
Data mining,Lookup table,Data structure,Identifier,Visualization,Computer science,Source code,Radix tree,Software,Bioinformatics,Memory footprint
Journal
Volume
Issue
ISSN
18
1
1471-2105
Citations 
PageRank 
References 
5
0.49
9
Authors
9