Paper Info
Title
Dynamical Conditions For The Containment Of Hiv Infection By Cd8+T Cells - A Variable Structure Control Approach
Abstract
In the study of the Human Immunodeficiency Virus (HIV) infection dynamics, the reproductive ratio is a well-known tool which provides a steady-state condition to determine the outcome of the infection. This paper assesses the control of HIV by the immune response. Dynamical conditions for the containment of HIV infection by the HIV-specific CD8+ T cell response are evaluated using a model of HIV dynamics in vivo in which HIV-infected cells are killed before they start producing new virion. The reachability paradigm from Variable Structure Control (VSC) theory is used to formulate a dynamical condition for immunity. Simulation results show that this reachability condition effectively monitors the immunological requirements to contain HIV. This work also suggests that the cytolytic killing mechanism of CD8+ T cells operates as a boundary layer control to contain HIV infection. Together, the findings indicate that in contrast to the reproductive ratio, the proposed VSC approach delivers a framework to assess the effects of nonlinear dynamics and uncertainty as well as providing a means to investigate immunotherapy strategies.
Year
Venue
Field
2017
2017 IEEE 56TH ANNUAL CONFERENCE ON DECISION AND CONTROL (CDC)
CD8,Computer science,Control theory,Immunity,Immunodeficiency,Immune system,Cytotoxic T cell,Variable structure control,Virology,T cell,Immunotherapy
DocType
ISSN
Citations 
Conference
0743-1546
0
PageRank 
References 
Authors
0.34
0
2
Name
Order
Citations
PageRank
Anet J. N. Anelone100.34
sarah k spurgeon272471.21