Paper Info
Title
NaviCom: a web application to create interactive molecular network portraits using multi-level omics data.
Abstract
Human diseases such as cancer are routinely characterized by high-throughput molecular technologies, and multi-level omics data are accumulated in public databases at increasing rate. Retrieval and visualization of these data in the context of molecular network maps can provide insights into the pattern of regulation of molecular functions reflected by an omics profile. In order to make this task easy, we developed NaviCom, a Python package and web platform for visualization of multi-level omics data on top of biological network maps. NaviCom is bridging the gap between cBioPortal, the most used resource of large-scale cancer omics data and NaviCell, a data visualization web service that contains several molecular network map collections. NaviCom proposes several standardized modes of data display on top of molecular network maps, allowing addressing specific biological questions. We illustrate how users can easily create interactive network-based cancer molecular portraits via NaviCom web interface using the maps of Atlas of Cancer Signalling Network (ACSN) and other maps. Analysis of these molecular portraits can help in formulating a scientific hypothesis on the molecular mechanisms deregulated in the studied disease.
Year
DOI
Venue
2017
10.1093/database/bax026
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Field
DocType
Volume
Data science,Network mapping,Data visualization,Visualization,Computer science,Biological network,Web application,Bioinformatics,Web service,User interface,Python (programming language)
Journal
2017
Issue
ISSN
Citations 
1
1758-0463
4
PageRank 
References 
Authors
0.41
12
5
Name
Order
Citations
PageRank
Mathurin Dorel140.41
Eric Viara213422.41
Emmanuel Barillot3950165.00
Andrei Zinovyev428227.30
Inna Kuperstein562.16