Paper Info
Title
Pharmmapper 2017 Update: A Web Server For Potential Drug Target Identification With A Comprehensive Target Pharmacophore Database
Abstract
The PharmMapper online tool is a web server for potential drug target identification by reversed pharmacophore matching the query compound against an in-house pharmacophore model database. The original version of PharmMapper includes more than 7000 target pharmacophores derived from complex crystal structures with corresponding protein target annotations. In this article, we present a new version of the PharmMapper web server, of which the back-end pharmacophore database is six times larger than the earlier one, with a total of 23 236 proteins covering 16 159 druggable pharmacophore models and 51 431 ligandable pharmacophore models. The expanded target data cover 450 indications and 4800 molecular functions compared to 110 indications and 349 molecular functions in our last update. In addition, the new web server is united with the statistically meaningful ranking of the identified drug targets, which is achieved through the use of standard scores. It also features an improved user interface. The proposed web server is freely available at http://lilab.ecust.edu.cn/pharmmapper/.
Year
DOI
Venue
2017
10.1093/nar/gkx374
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Pharmacophore,Biology,Drug target,Computational biology,Bioinformatics,Genetics,Web server
Journal
45
Issue
ISSN
Citations 
W1
0305-1048
3
PageRank 
References 
Authors
0.39
17
9
Name
Order
Citations
PageRank
Xia Wang1111.19
Yihang Shen230.73
Shiwei Wang38712.09
Shiliang Li430.39
Weilin Zhang5156.12
Xiaofeng Liu61455.72
Luhua Lai736933.78
Jianfeng Pei8416.72
Honglin Li925618.16