Name
Abstract | ||
|---|---|---|
The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for speed of signal conduction, cellular energetics, and spatial constraints. In vivo imaging of the g-ratio in health and disease would greatly increase our knowledge of the nervous system and our ability to diagnose, monitor, and treat disease. MRI based g-ratio imaging was first conceived in 2011, and expanded to be feasible in full brain white matter with preliminary results in 2013. This manuscript reviews the growing g-ratio imaging literature and speculates on future applications. It details the methodology for imaging the g-ratio with MRI, and describes the known pitfalls and challenges in doing so. |
Year | DOI | Venue |
|---|---|---|
2018 | 10.1016/j.neuroimage.2017.08.038 | NeuroImage |
Keywords | Field | DocType |
g-ratio,MRI,Myelin imaging,Diffusion MRI,White matter,Microstructure | Neuroscience,White matter,Psychology,Neuroimaging,Brain White Matter,Preclinical imaging,Myelin,Myelinated axon | Journal |
Volume | ISSN | Citations |
182 | 1053-8119 | 11 |
PageRank | References | Authors |
0.52 | 39 | 8 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jennifer S W Campbell | 1 | 255 | 18.91 |
| Ilana R. Leppert | 2 | 48 | 1.74 |
| Sridar Narayanan | 3 | 166 | 11.38 |
| Mathieu Boudreau | 4 | 48 | 2.08 |
| Tanguy Duval | 5 | 83 | 5.27 |
| Julien Cohen-Adad | 6 | 472 | 29.21 |
| G Bruce Pike | 7 | 699 | 132.31 |
| Nikola Stikov | 8 | 104 | 7.79 |