Title
High resolution volumetric imaging of primary and secondary tumor spheroids using multi-angle Light Sheet Fluorescence Microscopy (LSFM).
Abstract
Breast cancer and Glioblastoma brain cancer are severe malignancies with poor prognosis. In this study, primary Glioblastoma and secondary breast cancer spheroids are formed and treated with the well-known Temozolomide and Doxorubicin chemotherapeutics, respectively. High resolution imaging of both primary and secondary cancer cell spheroids is possible using a custom multi-angle Light Sheet Fluorescence Microscope. Such a technique is successful in realizing preclinical drug screening, while enables the discrimination among physiologic tumor parameters.
Year
DOI
Venue
2018
10.1109/EMBC.2018.8512388
EMBC
Field
DocType
Volume
Computer vision,Fluorescence microscope,Spheroid,Breast cancer,Temozolomide,Computer science,Light sheet fluorescence microscopy,Doxorubicin,Cancer research,Artificial intelligence,Microscopy,Cancer
Conference
2018
Citations 
PageRank 
References 
0
0.34
0
Authors
7