Paper Info
Title
Eggnog 5.0: A Hierarchical, Functionally And Phylogenetically Annotated Orthology Resource Based On 5090 Organisms And 2502 Viruses
Abstract
eggNOG is a public database of orthology relationships, gene evolutionary histories and functional annotations. Here, we present version 5.0, featuring a major update of the underlying genome sets, which have been expanded to 4445 representative bacteria and 168 archaea derived from 25 038 genomes, as well as 477 eukaryotic organisms and 2502 viral proteomes that were selected for diversity and filtered by genome quality. In total, 4.4M orthologous groups (OGs) distributed across 379 taxonomic levels were computed together with their associated sequence alignments, phylogenies, HMM models and functional descriptors. Precomputed evolutionary analysis provides fine-grained resolution of duplication/speciation events within each OG. Our benchmarks show that, despite doubling the amount of genomes, the quality of orthology assignments and functional annotations (80% coverage) has persisted without significant changes across this update. Finally, we improved eggNOG online services for fast functional annotation and orthology prediction of custom genomics or metagenomics datasets. All precomputed data are publicly available for downloading or via API queries at http://eggnog.embl.de
Year
DOI
Venue
2019
10.1093/nar/gky1085
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Genome,Sequence alignment,Annotation,Biology,Genomics,Metagenomics,Proteome,Computational biology,Phylogenetics,Taxonomic rank,Genetics
Journal
47
Issue
ISSN
Citations 
D1
0305-1048
0
PageRank 
References 
Authors
0.34
16
12
Name
Order
Citations
PageRank
Jaime Huerta-Cepas153729.38
Damian Szklarczyk2111749.06
Davide Heller32478.50
Ana Hernández-Plaza400.34
Sofia K Forslund500.68
Helen Cook6602.80
Daniel R. Mende7453.18
Ivica Letunic81650255.45
Thomas Rattei943631.40
Lars Juhl Jensen102202137.56
Christian von Mering111905119.64
Peer Bork124451694.12