Paper Info
Title
CART-a chemical annotation retrieval toolkit.
Abstract
Motivation: Data on bioactivities of drug-like chemicals are rapidly accumulating in public repositories, creating new opportunities for research in computational systems pharmacology. However, integrative analysis of these data sets is difficult due to prevailing ambiguity between chemical names and identifiers and a lack of cross-references between databases. Results: To address this challenge, we have developed CART, a Chemical Annotation Retrieval Toolkit. As a key functionality, it matches an input list of chemical names into a comprehensive reference space to assign unambiguous chemical identifiers. In this unified space, bioactivity annotations can be easily retrieved from databases covering a wide variety of chemical effects on biological systems. Subsequently, CART can determine annotations enriched in the input set of chemicals and display these in tabular format and interactive network visualizations, thereby facilitating integrative analysis of chemical bioactivity data.
Year
DOI
Venue
2016
10.1093/bioinformatics/btw233
BIOINFORMATICS
Field
DocType
Volume
Data mining,Data set,Annotation,Identifier,Information retrieval,Chemical nomenclature,Cart,Source code,Computer science,Bioinformatics,Web service,Ambiguity
Journal
32
Issue
ISSN
Citations 
18
1367-4803
2
PageRank 
References 
Authors
0.39
8
7
Name
Order
Citations
PageRank
Samy Deghou120.39
Georg Zeller21217.11
Murat Iskar3804.95
Marja Driessen490.90
Mercedes Castillo520.39
Vera van Noort61157.74
Peer Bork74451694.12