Name
Title | ||
|---|---|---|
Icircda-Mf: Identification Of Circrna-Disease Associations Based On Matrix Factorization |
Abstract | ||
|---|---|---|
Circular RNAs (circRNAs) are a group of novel discovered non-coding RNAs with closed-loop structure, which play critical roles in various biological processes. Identifying associations between circRNAs and diseases is critical for exploring the complex disease mechanism and facilitating disease-targeted therapy. Although several computational predictors have been proposed, their performance is still limited. In this study, a novel computational method called iCircDA-MF is proposed. Because the circRNA-disease associations with experimental validation are very limited, the potential circRNA-disease associations are calculated based on the circRNA similarity and disease similarity extracted from the disease semantic information and the known associations of circRNA-gene, gene-disease and circRNA-disease. The circRNA-disease interaction profiles are then updated by the neighbour interaction profiles so as to correct the false negative associations. Finally, the matrix factorization is performed on the updated circRNA-disease interaction profiles to predict the circRNA-disease associations. The experimental results on a widely used benchmark dataset showed that iCircDA-MF outperforms other state-of-the-art predictors and can identify new circRNA-disease associations effectively. |
Year | DOI | Venue |
|---|---|---|
2020 | 10.1093/bib/bbz057 | BRIEFINGS IN BIOINFORMATICS |
Keywords | DocType | Volume |
circRNA-disease associations, matrix factorization, circRNA similarity, disease similarity | Journal | 21 |
Issue | ISSN | Citations |
4 | 1467-5463 | 1 |
PageRank | References | Authors |
0.36 | 0 | 2 |