Paper Info
Title
Semi-Disparate Impact of Kinases GCN2 and PERK in Modulating the Dynamic Control Properties of eIF2 Pathway.
Abstract
The tumor microenvironment associated with deficiencies in nutrients and oxygen is important in observing the regulation of tumor progression. The aggressiveness of the tumor cells can be stimulated by exposing it to nutrient starvation and hypoxia. During nutrient starvation, activation of an integrated stress response pathway takes place, which helps tumor cells to cope with nutrient stress. In this paper, an evolutionarily conserved central translational control pathway, i.e., the integrated stress response pathway is analyzed with the help of a mathematical model. This paper is of significant novelty in terms of testable predictions about specific pathway properties with the help of analysis tools from control theory. The investigation has suggested that both kinases GCN2 and PERK have semi-disparate impact on the dynamic control properties of the system. The examples include both kinases show analogous behavior toward the robustness and stability of the system, but disparate behavior in compensating the loss of another kinase.
Year
DOI
Venue
2019
10.1109/ACCESS.2019.2918216
IEEE ACCESS
Keywords
Field
DocType
Bode analysis,linear system,mathematical modeling,protein synthesis,robustness,stability,biophysics
Tumor microenvironment,Analysis tools,Tumor progression,eIF2,Computer science,Kinase,Cell biology,Integrated stress response,Distributed computing
Journal
Volume
ISSN
Citations 
7
2169-3536
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
Mohammad Farhan Khan191.15
sarah k spurgeon272471.21
Muaffaq M. Nofal300.68
xinggang yan447146.12