Paper Info
Title
Dynamic Activation Patterns Of The Motor Brain Revealed By Diffuse Optical Tomography
Abstract
Diffuse optical tomography (DOT), a subset of functional near-infrared spectroscopy (fNIRS), is a noninvasive functional imaging modality for studying the human brain in normal and diseased conditions. It measures changes in concentrations of oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (Hb) in the blood vasculature of the brain. In contrast to functional magnetic resonance imaging (fMRI), the gold standard in human brain imaging, DOT offers the advantage of higher temporal resolution, portability, lower cost, multiple contrasts and usability for persons who cannot otherwise utilize MRI-based imaging modalities, including bedridden patients and infants, etc. The goal of the present study was to evaluate performance of a DOT method in studying dynamic patterns of brain activations involving motor control. CW-fNIRS data were acquired in four sessions from a healthy male participant when he performed a motor task in a block-design experiment. Results from experimental data showed pronounced activity in the primary motor cortex (Ml), contralateral to the clenching hand. It was further observed that the M1 activity was consistent over four sessions. Furthermore, temporal dynamics of motor activity at each session further revealed well-sequenced activation patterns among Ml, premotor cortex (PMC), and supplementary motor area (SMA). Timed ipsilateral motor activity suppression was also observed several seconds after the onset of contralateral M1 activity. More importantly, these temporal dynamics were similarly observed in all four sessions. These preliminary results suggest that the DOT method has the sensitivity, reliability, and spatio-temporal resolutions to study activities originated from the motor cortices. A full-scope evaluation and validation in more participants on the motor system can establish it as a promising neuroimaging tool to study, such as, infants at the risk of cerebral palsy or elders with Parkinson's due to its portability and usability in clinical environments.
Year
DOI
Venue
2019
10.1109/EMBC.2019.8857370
2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
Field
DocType
Volume
Computer vision,Neuroscience,Functional magnetic resonance imaging,Premotor cortex,Computer science,Functional imaging,Motor control,Supplementary motor area,Human brain,Artificial intelligence,Neuroimaging,Primary motor cortex
Conference
2019
ISSN
Citations 
PageRank 
1557-170X
0
0.34
References 
Authors
0
4
Name
Order
Citations
PageRank
Ali F. Khan100.34
Fan Zhang201.35
Han Yuan300.34
Lei Ding414226.77