Title
Tear Film Classification in Interferometry Eye Images Using Phylogenetic Diversity Indexes and Ripley's K Function
Abstract
Dry eye syndrome is one of the most frequently reported eye diseases in ophthalmological practice. The diagnosis of this disease is a challenging task due to its multifactorial etiology. One of the most applied tests is the manual classification of tear film images captured with the Doane interferometer. The interference phenomena in these images can be characterized as texture patterns, which can be automatically classified into one of the following categories: strong fringes, coalescing strong fringes, fine fringes, coalescing fine fringes, and debris. This work presents a method for classifying tear film images based on texture analysis using phylogenetic diversity indexes and Ripley's K function. The proposed method consists of six main steps: acquisition of the image dataset; segmentation of the region of interest; feature extraction using phylogenetic diversity indexes and Ripley's K function; feature selection using Greedy Stepwise; classification using the algorithms Support Vector Machine (SVM), Random Forest (RF), Naive Bayes (NB), Multilayer Perceptron (MLP), Random Tree (RT) and Radial Basis Function Network (RBFNet); and (6) validation of results. The best result, using the RF classifier, we obtained classification rates higher than 99% of accuracy with 0.843% of standard deviation, 0.999 of the area under the Receiver Operating Characteristics (ROC) curve, 0.995 of Kappa and 0.996 of F-Measure. The experimental results demonstrate that the proposed method is promising and can potentially be used by experts to accurately diagnose dry eye syndrome in tear film images.
Year
DOI
Venue
2020
10.1109/JBHI.2020.3026940
IEEE Journal of Biomedical and Health Informatics
Keywords
DocType
Volume
Adolescent,Adult,Algorithms,Dry Eye Syndromes,Humans,Image Interpretation, Computer-Assisted,Interferometry,Middle Aged,Support Vector Machine,Tears,Young Adult
Journal
24
Issue
ISSN
Citations 
12
2168-2194
1
PageRank 
References 
Authors
0.35
0
8