Title
A simple estimate of axon size with diffusion MRI
Abstract
•Monte Carlo simulations of diffusion MRI suggest a simple metric of axon diameter-the change in the radial apparent diffusion coefficient estimated at different diffusion times, ΔD⊥.•ΔD⊥ increased with effective mean axon diameter, and was relatively independent of extra-axonal volume fraction, g-ratio, myelin water exchange, and the free diffusion coefficient of water.•The slope of ΔD⊥ increased with the difference in effective diffusion time of the diffusion encoding waveforms.•Both extra- and intra-axonal water can contribute to ΔD⊥, providing sensitivity to small and large axon diameters, respectively.
Year
DOI
Venue
2021
10.1016/j.neuroimage.2020.117619
NeuroImage
Keywords
DocType
Volume
Diffusion,MRI,Oscillating gradient,Pulsed gradient,White matter,Axon,Diameter,Monte Carlo
Journal
227
ISSN
Citations 
PageRank 
1053-8119
0
0.34
References 
Authors
0
5
Name
Order
Citations
PageRank
Kevin D Harkins100.34
Christian Beaulieu220914.88
Junzhong Xu3171.49
John C Gore461641.36
Mark D. Does5986.30