Abstract | ||
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•Monte Carlo simulations of diffusion MRI suggest a simple metric of axon diameter-the change in the radial apparent diffusion coefficient estimated at different diffusion times, ΔD⊥.•ΔD⊥ increased with effective mean axon diameter, and was relatively independent of extra-axonal volume fraction, g-ratio, myelin water exchange, and the free diffusion coefficient of water.•The slope of ΔD⊥ increased with the difference in effective diffusion time of the diffusion encoding waveforms.•Both extra- and intra-axonal water can contribute to ΔD⊥, providing sensitivity to small and large axon diameters, respectively. |
Year | DOI | Venue |
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2021 | 10.1016/j.neuroimage.2020.117619 | NeuroImage |
Keywords | DocType | Volume |
Diffusion,MRI,Oscillating gradient,Pulsed gradient,White matter,Axon,Diameter,Monte Carlo | Journal | 227 |
ISSN | Citations | PageRank |
1053-8119 | 0 | 0.34 |
References | Authors | |
0 | 5 |
Name | Order | Citations | PageRank |
---|---|---|---|
Kevin D Harkins | 1 | 0 | 0.34 |
Christian Beaulieu | 2 | 209 | 14.88 |
Junzhong Xu | 3 | 17 | 1.49 |
John C Gore | 4 | 616 | 41.36 |
Mark D. Does | 5 | 98 | 6.30 |